S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cdc45p
Description	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
GO Terms: Biological Process	level 3: cell cycle level 5: mitotic DNA replication preinitiation complex assembly level 6: DNA replication level 6: DNA replication initiation level 9: double-strand break repair via break-induced replication
GO Terms: Molecular Function	level 3: chromatin binding level 6: single-stranded DNA binding level 8: DNA replication origin binding
GO Terms: Cellular Component	level 4: DNA replication preinitiation complex level 4: replication fork protection complex level 4: nuclear replication fork level 5: CMG complex level 5: nucleus
External source	Open in SGD