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Gene Ontology Information

Protein Name Dph6p
Description Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
GO Terms:
Biological Process		 level 5: peptidyl-diphthamide biosynthetic process from peptidyl-histidine external link
GO Terms:
Molecular Function		 level 3: ligase activity external link
level 4: nucleotide binding external link
level 6: diphthine-ammonia ligase activity external link
level 6: ATP binding external link
GO Terms:
Cellular Component		 level 3: cytoplasm external link
External source Open in SGD external link
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