S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ski2p
Description	Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome
GO Terms: Biological Process	level 5: defense response to virus level 6: RNA catabolic process level 7: regulation of translation level 9: nuclear-transcribed mRNA catabolic process, non-stop decay level 10: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay level 10: nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO Terms: Molecular Function	level 3: helicase activity level 3: hydrolase activity level 4: RNA helicase activity level 4: nucleotide binding level 4: nucleic acid binding level 5: DNA binding level 5: RNA binding level 6: mRNA binding level 6: ATP binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: Ski complex
External source	Open in SGD