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Gene Ontology Information

Protein Name Cdc73p
Description Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers
GO Terms:
Biological Process
level 6: histone modification external link
level 7: recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex external link
level 8: transcription elongation by RNA polymerase I external link
level 8: transcription elongation by RNA polymerase II promoter external link
level 8: mRNA 3'-end processing external link
level 8: negative regulation of DNA recombination external link
level 9: positive regulation of histone H3-K36 trimethylation external link
level 9: regulation of transcription-coupled nucleotide-excision repair external link
level 10: positive regulation of transcription elongation by RNA polymerase I external link
level 10: positive regulation of transcription elongation by RNA polymerase II external link
level 11: regulation of histone H2B conserved C-terminal lysine ubiquitination external link
level 11: positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues external link
GO Terms:
Molecular Function
level 3: chromatin binding external link
level 6: RNA polymerase II complex binding external link
level 7: RNA polymerase II C-terminal domain phosphoserine binding external link
GO Terms:
Cellular Component
level 3: nucleoplasm external link
level 4: euchromatin external link
level 5: Cdc73/Paf1 complex external link
level 5: nucleus external link
External source Open in SGD external link
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