S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sir3p
Description	Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication
GO Terms: Biological Process	level 4: establishment of protein-containing complex localization to telomere level 6: telomere tethering at nuclear periphery level 8: heterochromatin formation level 8: subtelomeric heterochromatin formation level 8: double-strand break repair via nonhomologous end joining level 8: negative regulation of DNA replication level 9: nuclear-transcribed mRNA catabolic process, non-stop decay level 10: silent mating-type cassette heterochromatin formation
GO Terms: Molecular Function	level 3: chromatin binding level 4: nucleosome binding level 5: DNA binding level 6: double-stranded DNA binding level 6: single-stranded DNA binding level 8: DNA replication origin binding
GO Terms: Cellular Component	level 4: chromatin silencing complex level 4: mitochondrion level 4: chromosome, telomeric region level 4: heterochromatin level 5: nucleus level 5: nucleolus
External source	Open in SGD