S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cdc5p
Description	Polo-like kinase essential for mitotic cell cycle; controls targeting, activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates shape of nucleus, expansion of nuclear envelope during mitosis; implicated in cell divisions in telomerase-negative strains through adaptation to DNA damage, which allows bypass of cell cycle arrest and contributes senescence-specific genome instability; human homologs PLK1, PLK3 can each complement cdc5 thermosensitive mutants
GO Terms: Biological Process	level 3: cell cycle level 3: cell division level 4: mitotic cell cycle level 5: positive regulation of cohesin unloading level 5: resolution of meiotic recombination intermediates level 5: meiotic spindle assembly level 6: regulation of cytokinesis level 6: protein phosphorylation level 6: exit from mitosis level 6: synaptonemal complex disassembly level 6: phosphorylation level 7: regulation of nucleus organization level 7: positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly level 8: regulation of protein localization to nucleolus level 8: negative regulation of protein localization to nucleolus level 8: positive regulation of mitotic spindle pole body separation level 8: regulation of protein localization to mitotic spindle pole body level 10: positive regulation of Rho protein signal transduction
GO Terms: Molecular Function	level 3: protein-containing complex binding level 3: transferase activity level 4: nucleotide binding level 4: phosphoprotein binding level 4: protein kinase activity level 5: kinase activity level 5: protein serine/threonine kinase activity level 6: ATP binding level 8: centromeric DNA binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: spindle pole level 4: spindle pole body level 4: cellular bud neck level 5: nucleus level 5: mitotic spindle pole body
External source	Open in SGD