S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Yta12p
Description	Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation
GO Terms: Biological Process	level 5: proteolysis level 6: signal peptide processing level 6: protein-containing complex assembly level 7: mitochondrial protein processing
GO Terms: Molecular Function	level 3: ATP-dependent peptidase activity level 3: hydrolase activity level 3: ATP hydrolysis activity level 4: peptidase activity level 4: nucleotide binding level 5: metal ion binding level 5: metallopeptidase activity level 6: metalloendopeptidase activity level 6: ATP binding level 7: zinc ion binding
GO Terms: Cellular Component	level 3: membrane level 3: cytoplasm level 3: mitochondrial inner boundary membrane level 4: integral component of membrane level 4: mitochondrion level 5: mitochondrial membrane level 5: m-AAA complex level 6: mitochondrial inner membrane
External source	Open in SGD