S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sgs1p
Description	RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant
GO Terms: Biological Process	level 3: gene conversion at mating-type locus level 4: meiotic chromosome segregation level 4: meiotic DNA double-strand break processing level 5: regulation of reciprocal meiotic recombination level 5: mitotic sister chromatid segregation level 6: chromosome organization level 6: negative regulation of meiotic joint molecule formation level 6: telomere maintenance level 6: DNA replication level 6: DNA topological change level 6: mitotic intra-S DNA damage checkpoint signaling level 6: DNA double-strand break processing level 6: DNA repair level 6: DNA recombination level 6: mitotic G2/M transition checkpoint level 7: telomere maintenance via recombination level 7: telomeric 3' overhang formation level 8: double-strand break repair via homologous recombination level 8: DNA unwinding involved in DNA replication level 9: DNA duplex unwinding level 9: G-quadruplex DNA unwinding
GO Terms: Molecular Function	level 3: hydrolase activity level 3: helicase activity level 4: nucleotide binding level 4: nucleic acid binding level 4: DNA helicase activity level 5: four-way junction helicase activity level 5: 3'-5' DNA helicase activity level 6: ATP binding level 7: zinc ion binding
GO Terms: Cellular Component	level 3: cytoplasm level 4: RecQ family helicase-topoisomerase III complex level 5: nucleus level 5: chromosome level 5: nucleolus
External source	Open in SGD