S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mre11p
Description	Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
GO Terms: Biological Process	level 3: meiotic cell cycle level 3: regulation of transcription involved in meiotic cell cycle level 4: ascospore formation level 4: reciprocal meiotic recombination level 4: meiotic DNA double-strand break processing level 5: cellular response to DNA damage stimulus level 5: meiotic DNA double-strand break formation level 6: DNA repair level 6: mitotic intra-S DNA damage checkpoint signaling level 6: mitotic G2 DNA damage checkpoint signaling level 6: telomere maintenance level 7: base-excision repair level 7: double-strand break repair level 7: maintenance of DNA trinucleotide repeats level 7: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing level 7: nucleoside monophosphate phosphorylation level 8: double-strand break repair via homologous recombination level 8: double-strand break repair via nonhomologous end joining level 8: mitochondrial double-strand break repair via homologous recombination level 9: double-strand break repair via break-induced replication
GO Terms: Molecular Function	level 2: molecular adaptor activity level 3: hydrolase activity level 5: nuclease activity level 6: G-quadruplex DNA binding level 6: endonuclease activity level 6: endodeoxyribonuclease activity level 6: exonuclease activity level 7: manganese ion binding level 7: double-stranded telomeric DNA binding level 7: adenylate kinase activity level 7: telomeric DNA binding level 7: 3'-5' exonuclease activity level 7: single-stranded DNA endodeoxyribonuclease activity level 8: 3'-5'-exodeoxyribonuclease activity level 8: single-stranded telomeric DNA binding
GO Terms: Cellular Component	level 4: Mre11 complex level 4: site of double-strand break level 4: mitochondrion level 5: nucleus
External source	Open in SGD