S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Msb3p
Description	Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null
GO Terms: Biological Process	level 5: exocytosis level 6: endocytosis level 6: regulation of protein localization level 6: regulation of GTPase activity level 8: formin-nucleated actin cable assembly level 8: activation of GTPase activity
GO Terms: Molecular Function	level 5: GTPase activator activity
GO Terms: Cellular Component	level 3: polarisome level 3: cytoplasm level 3: cytosol level 3: cell periphery level 3: cellular bud level 4: mating projection tip level 4: plasma membrane level 4: cellular bud tip level 4: cellular bud neck level 4: incipient cellular bud site level 5: late endosome level 7: fungal-type vacuole membrane
External source	Open in SGD