S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Top1p
Description	Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation
GO Terms: Biological Process	level 3: chromosome segregation level 5: mitotic chromosome condensation level 5: nuclear migration level 5: chromatin organization level 6: DNA replication level 6: DNA topological change level 6: rDNA heterochromatin formation level 7: DNA strand elongation involved in DNA replication level 8: regulation of transcription by RNA polymerase II level 8: transcription elongation by RNA polymerase II promoter level 8: regulation of mitotic recombination level 9: rRNA transcription
GO Terms: Molecular Function	level 3: isomerase activity level 4: DNA topoisomerase activity level 5: DNA topoisomerase type I (single strand cut, ATP-independent) activity level 5: DNA binding
GO Terms: Cellular Component	level 3: nucleoplasm level 4: replication fork protection complex level 5: nucleus level 5: chromosome level 5: nucleolus
External source	Open in SGD