S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Msh2p
Description	Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; required for silencing at the silent mating-type loci and telomeres
GO Terms: Biological Process	level 5: meiotic gene conversion level 5: meiotic mismatch repair level 5: cellular response to DNA damage stimulus level 6: DNA recombination level 6: removal of nonhomologous ends level 6: DNA repair level 7: mismatch repair level 7: mitotic recombination level 7: interstrand cross-link repair level 7: replication fork arrest level 10: silent mating-type cassette heterochromatin formation
GO Terms: Molecular Function	level 3: ATP hydrolysis activity level 4: ATP-dependent DNA damage sensor activity level 4: nucleotide binding level 5: DNA binding level 6: double-stranded DNA binding level 6: ATP binding level 7: four-way junction DNA binding level 7: Y-form DNA binding level 7: heteroduplex DNA loop binding level 7: double-strand/single-strand DNA junction binding level 7: mismatched DNA binding level 8: DNA insertion or deletion binding level 8: guanine/thymine mispair binding level 9: single base insertion or deletion binding
GO Terms: Cellular Component	level 3: mismatch repair complex level 4: MutSalpha complex level 4: MutSbeta complex level 5: nucleus level 6: nuclear chromosome
External source	Open in SGD