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Gene Ontology Information

Protein Name Sgt2p
Description Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
GO Terms:
Biological Process		 level 4: response to heat external link
level 7: post-translational protein targeting to endoplasmic reticulum membrane external link
level 7: ubiquitin-dependent ERAD pathway external link
GO Terms:
Molecular Function		 level 2: molecular adaptor activity external link
GO Terms:
Cellular Component		 level 3: cytoplasm external link
level 3: membrane external link
level 4: TRC complex external link
External source Open in SGD external link
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