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Gene Ontology Information

Protein Name Ddl1p
Description DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism
GO Terms:
Biological Process		 level 4: lipid metabolic process external link
level 5: phospholipid metabolic process external link
level 5: lipid catabolic process external link
level 7: phosphatidylethanolamine metabolic process external link
level 8: cardiolipin metabolic process external link
GO Terms:
Molecular Function		 level 3: hydrolase activity external link
level 5: metal ion binding external link
level 6: phospholipase activity external link
GO Terms:
Cellular Component		 level 3: cytoplasm external link
level 4: mitochondrion external link
level 5: mitochondrial matrix external link
External source Open in SGD external link
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