S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cue5p
Description	Ubiquitin-binding protein; functions as ubiquitin-Atg8p adaptor in ubiquitin-dependent autophagy; serves as proteaphagy receptor for inactivated 26S proteasomes; contains CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE5 has a paralog, DON1, that arose from the whole genome duplication; human TOLLIP is a functional CUE-domain homolog, can complement yeast null mutant, rescuing hypersensitivity of cue5 null mutant cells to Htt-96Q
GO Terms: Biological Process	level 4: autophagy level 8: ubiquitin-dependent protein catabolic process
GO Terms: Molecular Function	level 3: protein-macromolecule adaptor activity level 5: ubiquitin binding level 6: ubiquitin conjugating enzyme binding level 6: K48-linked polyubiquitin modification-dependent protein binding level 6: K63-linked polyubiquitin modification-dependent protein binding
GO Terms: Cellular Component	level 3: cytoplasm
External source	Open in SGD