Gene Ontology Information
Locus Info
Protein Info
GO Info
Orthologs
Protein Name
Rat1p Description
Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation
GO Terms:
level 4: nucleobase-containing compound metabolic process DNA-templated transcription termination rRNA processing mRNA processing sno(s)RNA processing mRNA splicing, via spliceosome RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA catabolic process NAD-cap decapping termination of RNA polymerase II transcription, poly(A)-coupled termination of RNA polymerase II transcription, exosome-dependent nuclear mRNA surveillance nuclear polyadenylation-dependent rRNA catabolic process cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) negative regulation of transcription elongation by RNA polymerase II negative regulation of phosphorylation of RNA polymerase II C-terminal domain GO Terms:
level 3: hydrolase activity nucleic acid binding nuclease activity RNA binding mRNA binding rRNA binding exonuclease activity 5'-3' exoribonuclease activity GO Terms:
level 4: mitochondrion nucleus External source
Open in SGD
