S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Tcb1p
Description	Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in PM; contains 3 calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; TCB1 has a paralog, TCB2, that arose from the whole genome duplication
GO Terms: Biological Process	level 5: endoplasmic reticulum-plasma membrane tethering level 5: lipid transport level 6: ER to Golgi ceramide transport level 6: regulation of phosphatidylinositol dephosphorylation level 6: endoplasmic reticulum membrane organization
GO Terms: Molecular Function	level 3: lipid binding level 5: calcium-dependent phospholipid binding level 5: metal ion binding
GO Terms: Cellular Component	level 3: membrane level 3: cell periphery level 4: integral component of membrane level 4: mitochondrion level 4: endoplasmic reticulum level 4: plasma membrane level 5: cortical endoplasmic reticulum level 5: endoplasmic reticulum membrane
External source	Open in SGD