S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Las17p
Description	Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches
GO Terms: Biological Process	level 4: actin cortical patch localization level 5: actin filament organization level 6: actin nucleation level 7: actin filament polymerization level 7: positive regulation of actin filament bundle assembly level 9: positive regulation of Arp2/3 complex-mediated actin nucleation
GO Terms: Molecular Function	level 4: Arp2/3 complex binding level 5: actin binding
GO Terms: Cellular Component	level 3: SLAC complex level 3: cytoplasm level 4: actin cortical patch level 4: mating projection tip
External source	Open in SGD