S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ded1p
Description	ATP-dependent DEAD-box RNA helicase with strand-annealing activity; promotes eIF4F-dependent 48S translation preinitiation complex (PIC) assembly, stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with Dbp1p in PIC attachment and scanning; ATPase activity stimulated by mRNA cap-associated factor binding; directly binds eIF4G; role in spliceosomal complex disassembly; mutation in human homolog DBY associated with male infertility; human homolog DDX3X complements the null
GO Terms: Biological Process	level 4: translational initiation level 5: translation level 8: spliceosomal complex disassembly level 8: positive regulation of formation of translation preinitiation complex
GO Terms: Molecular Function	level 3: hydrolase activity level 3: helicase activity level 4: nucleic acid binding level 4: RNA helicase activity level 4: nucleotide binding level 5: RNA binding level 5: eukaryotic initiation factor 4G binding level 5: translation initiation factor activity level 6: mRNA binding level 6: RNA strand annealing activity level 6: ATP binding
GO Terms: Cellular Component	level 3: cytoplasm level 5: cytoplasmic stress granule level 5: nucleus
External source	Open in SGD