Yeastract
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Gene Ontology Information

Protein Name Pac1p
Description Regulator of dynein, involved in intracellular transport; part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
GO Terms:
Biological Process
level 3: cell division external link
level 3: microtubule-based process external link
level 3: cell cycle external link
level 4: microtubule organizing center organization external link
level 5: microtubule sliding external link
level 5: establishment of mitotic spindle orientation external link
level 5: nuclear migration external link
level 6: nuclear migration along microtubule external link
level 6: vesicle transport along microtubule external link
level 8: positive regulation of microtubule plus-end binding external link
GO Terms:
Molecular Function
level 4: dynein complex binding external link
level 7: microtubule plus-end binding external link
GO Terms:
Cellular Component
level 3: cytoplasm external link
level 3: microtubule associated complex external link
level 3: spindle pole external link
level 4: cytoplasmic microtubule external link
level 4: kinetochore external link
level 4: nuclear envelope external link
level 5: cytoskeleton external link
level 5: nucleus external link
level 7: microtubule external link
External source Open in SGD external link
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