S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Spp1p
Description	Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by interacting with H3K4me3 and Rec107p, a protein required for Spo11p-catalyzed DSB formation located on chromosome axes; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to cytosol in response to hypoxia
GO Terms: Biological Process	level 5: regulation of meiotic DNA double-strand break formation level 7: regulation of DNA-templated transcription level 8: subtelomeric heterochromatin formation level 8: positive regulation of DNA-templated transcription level 8: histone H3-K4 methylation
GO Terms: Molecular Function	level 3: chromatin binding level 5: methylated histone binding level 5: metal ion binding level 7: zinc ion binding level 7: histone methyltransferase activity (H3-K4 specific)
GO Terms: Cellular Component	level 3: cytosol level 4: chromosome, telomeric region level 5: Set1C/COMPASS complex level 5: nucleus
External source	Open in SGD