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Modelling prediction
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[metab] Optimisation
manipulating gene expression
manipulating TF expression
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Gene Ontology Information
Locus Info
Protein Info
GO Info
Orthologs
Protein Name
Aft2p
Description
Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication
GO Terms:
Biological Process
level 5:
cellular response to oxidative stress
level 8:
cardiolipin metabolic process
level 8:
positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
level 9:
positive regulation of transcription by RNA polymerase II
level 9:
regulation of phosphate transmembrane transport
level 9:
cellular iron ion homeostasis
GO Terms:
Molecular Function
level 4:
iron-sulfur cluster binding
level 4:
DNA-binding transcription factor activity, RNA polymerase II-specific
level 5:
DNA-binding transcription activator activity, RNA polymerase II-specific
level 7:
zinc ion binding
level 8:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO Terms:
Cellular Component
level 4:
mitochondrion
level 5:
nucleus
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