S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ipl1p
Description	Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest
GO Terms: Biological Process	level 3: cell cycle level 3: chromosome segregation level 4: attachment of spindle microtubules to kinetochore level 5: mitotic DNA integrity checkpoint signaling level 5: homologous chromosome segregation level 5: mitotic spindle organization level 5: meiotic sister chromatid segregation level 5: mitotic spindle disassembly level 6: phosphorylation level 6: regulation of cytokinesis level 6: protein phosphorylation level 8: regulation of mitotic cell cycle spindle assembly checkpoint level 8: regulation of mitotic spindle assembly level 9: negative regulation of protein import into nucleus during spindle assembly checkpoint
GO Terms: Molecular Function	level 3: transferase activity level 4: nucleotide binding level 4: protein kinase activity level 5: protein serine/threonine kinase activity level 5: kinase activity level 6: ATP binding level 6: histone serine kinase activity
GO Terms: Cellular Component	level 3: spindle midzone level 3: cytoplasm level 4: chromosome passenger complex level 4: chromosome, centromeric region level 4: kinetochore level 5: nucleus level 5: chromosome level 5: spindle level 5: cytoskeleton level 6: spindle microtubule level 7: kinetochore microtubule level 7: microtubule
External source	Open in SGD