S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Tif3p
Description	Translation initiation factor eIF-4B; RNA recognition motif containing single-stranded RNA binding protein that possesses RNA annealing and strand-exchange activities; stimulates the ATPase and unwinding activities of the RNA helicase eIF4A, in a synergistic manner with eIF4G; promotes assembly of the translation initiation factor complex eIF4F and the 48S preinitiation complex; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel
GO Terms: Biological Process	level 4: translational initiation level 5: translation level 5: positive regulation of ATP-dependent activity level 6: cytoplasmic translation level 6: regulation of RNA helicase activity level 6: formation of translation preinitiation complex level 7: eukaryotic translation initiation factor 4F complex assembly
GO Terms: Molecular Function	level 4: nucleic acid binding level 5: ribosomal small subunit binding level 5: RNA binding level 5: translation initiation factor activity level 6: single-stranded RNA binding level 6: mRNA binding level 6: RNA strand annealing activity level 7: RNA strand-exchange activity
GO Terms: Cellular Component	level 5: cytoplasmic stress granule
External source	Open in SGD