Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name NPL4
Systematic Name YBR170C
Alias HRD4
Strain S288c
Description Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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Promoter Sequence
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>NPL4 YBR170C
TATACTTTATAACTATTTTTTAACGCAGATAATGACAAATTCTATACATATTTTTAAAAA
AACACTGAACGAGCGAATACATATCTTTGCACACAGTAGGCACTAATTGACTAATCTTCC
ATCATTATTTATTTTCAGCTCCCACTCTTTAATACACACTTCTTTCCGTTTCAAGATTGA
TTGATAACGTCTAGAGAGAGCTTGATTAAAGCAAATTTCTTTACAAACCATAACGAACAA
TTGAACCCAGCCCGGTTGCAATCTTTCAGCTTCTTGTAAAGTATCTTTAAATTCCAATTC
AATTAATTTAACTTCAGTTTCAAATCTCTTCCAGTAATCCTCCCCAATAGAGCCATTTTT
ATATAGAAGGTTTATCTGAGGAGCCAACTCTTTTAACTTTAATGATCGTCTAACAGATTC
TGCTCCTCTGTTCAATAAAGCGGCCTTCAACACCTTCTCGTGAATTTTTTCATTTTCACT
CATTTCCTTTATTTGGAAATACAGATCATGGGCATCGTTTTCGTCAAATATGGATGGTTG
CTCACTAATTTTTTTGGCCTGCTTCTTTCTGTAGCTTGAAGCAAACATCACAAGGGACAC
CACCAGAATAAAGACATATATGAGTGGGGTATAAACGGAGATTGATTTCGTCTCCACAAT
TGGCTCTTCCGTTTCAAAAAACGTCCCGTTGTTGGAGAATTTTGTTTCATTAAATTCGGA
CATATTGGCAAACTCAAGTAGTTGTGCGTACCTCTTTCCTGTACTTGAATTCGTTTAAAT
AAGCCATTTCATTAATATTTCATCAATTTTTTCACATATTATTTCAACTTTTAGACGTGT
TCCTAAAACTTTTGACGTTTTTTGGCGGGTAATAAGATGCGTCTACCCATTTTAAGGAAC
GCCCTCGTAACATACAGAACGAAGAGTGGCAAATAATAGGACAGTACTCTGAAGAAAAAT
TTCCCTATACTACTGATATCGATATACATTTAAGTGAAGT
Chr coordinates Chr II from 578086-576344
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