Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name PPH22
Systematic Name YDL188C
Alias PPH2
Strain S288c
Description Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph21p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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Promoter Sequence
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>PPH22 YDL188C
TTGCGTTTCCACCAATCGGTAAACGATTCTACAATGGAACGCACGGATTCATCTCTCTTT
GTTGAACCAAATGGATCCGATCTTCTCGAGTTGAATTGTGCTGTGCTAAGCTGATATGGA
TGCGTGCCATTAATAGCTTCAATTGCGCCACGATGTGAAGATGCAGGTGGCCTCCATTTT
ACAAGTACGTCCTCCATTTTTCCCACAAATACATTTTCTTCTCTTCTTCTTCTGCTTTTT
TGTTTCGAAATCACGAGTTGCCTCACAGAGGGGAACTCACTTCTTGGTAAGAATCTGTTT
TGAGCCTCCGCTTCAGGGCTGTAGGATGGGAAAGTTATGTCGCCCCCATCTAAACCATCT
TCTATACTTGTGTTACACTGCATATTTTTCTAATATTTCTTGGCTATCTGTAAGCAAATC
TACATCCAGGAATAGAGTCCACAAGTATATTCCATATAAAAGCACAGAACTACGAAGTGT
CGCAAATTAGTTGTTTTTTTGGGAACTTGAACCCATACACCGCACCAAATTATTACAATA
TTTTGTGACACAGGACAGAATATTAATAAAAGAAGCGAAACTCTATTCTCCTAAAACTTC
TTCTTGCGGAATTATGTATCAATTAATGCTAAGATTAATCCAAAAGCTTATACGACAACA
ATAGTCGTTGTGCACTTTGAAATACAATCGTGTATTACCCTGACATGACCGGGTAATCTA
GAAGAGGTTATTATTTTCTTTTCCGCTGAATTGTGGAAAAGAGTCGTGGAAAGTTTCAAA
GGGACATCCCCATTTTATAAAACCAATTGAAGGGCTGTAACTAGAGCAAACTTCTTAAGG
TACCAGCCCGCTGCAAAACAGTGTTCGAACAAGAACACGCAAACCCGTTTACTTCTTGTC
CTACCTGCTCTCTTTCCTTTCCGGTTATTGTTCCTGTTACGTCTTTTTTTGAATTTTATA
TTATTGGCACTTCTGTATAACTGGCTTTCATTCGAAAAAA
Chr coordinates Chr IV from 124998-123865
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