Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name SAC6
Systematic Name YDR129C
Alias ABP67, fimbrin
Strain S288c
Description Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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Promoter Sequence
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>SAC6 YDR129C
GTCTCTAAGGAAACTCAAAGCCTGGATAGGCCTCAGTTCAAAAATTCGAATAAAAATGTG
AAGATCCAAAACTCAGATCATATAACTAATATAATATTCCCTACATCACCAACCAAACTG
ACATTCAGTAATGAAAATAAAATCGGGGGTGATGGTTCGTTAACGAGAATACGGGCCCGG
TTTAAGAATGGACTCATGTCACCTGAAAGGATACAGCAGCAACAGCAGCAACATATTCTC
CCATCGGATGCCAAAAGCAACACTGACCTCTGTTCTAATACTGAGCTCAAGGACGCCCCA
TTTGAGAATGACCTTCCTCGAGCTAAATTGAAAGGGAAGAATTTATTAGTTGAACTCAAG
AAAGAAGAGGAAGACGTGGGAAATGGCATAGAATCCCTTACTAAATCGAACACTAAACTG
AATTCCATGCTGGCGAACGAAGGTAAGATACACAAAGCTAGTTTCCAGAAAAGTGTAAAA
TTTAAACTACCTGATAATATAGTGACTGAAGAAACCGTGGAACTTAAAGAAATAAAGGAC
TTGCTACTACAAATGTTGAGAAGACAGCGAGAGATTGAATCAAGATTATCCAATATCGAA
CTTCAACTCACGGAAATACCGAAACATAAGTAATCATATCCCTTCTCACATTTTTTACAC
AGGAAGTAAGCAAGTTATGTTATATTTCCGACACTATAATTAATTCTTAGCAGTTAAAGG
TGCTTTGTCTATATTACATTTACATACAGCTTGAGTGATCCTGACCGGATATAGGGTCCT
ATTTTCTTACGTGAACGGCTTTTCTTCTTGTTCCCGATGGCCTTCATGTGAAAAAGCACT
CCTCGGGAGGCGGAAAAATATCAAAAGTACGGGGCGAAGTTTATAATGAAGATTTATCGA
TATAAATTTTGGTTATTTCAGGAGAACAAGAAAGCTCTTTACACTAAAATTATCAGAGAA
GAAGCTGATATATTAGCCCTAAGGAGTACACCAAAACACA
Chr coordinates Chr IV from 715247-713340,715379-715359
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