Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
SAN1
Systematic Name
YDR143C
Strain
S288c
Description
Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>SAN1 YDR143C
ATGAGTGAAAGTGGTCAAGAACAAAACAGAGGCACAAATACATCACCAAATAATGCTGAA
AATAATAATAATTCAAATGCAGCTTCCGGTCCACTCAATGGTGGTGCTGAGCAAACAAGA
AACATAACCGTTTCCATTCAGTATTCCTATTTCACTCCGGAGAGATTAGCACATTTGAGC
AATATATCTAATAATGATAATAACGAAAACAACAGCGCAGCATCCGGTAGCACGATTGCC
AACGGTACTGGGCCCAGCTTTGGCATCGGAAATGGGGGCCATCAACCCGACGGTGCTCTT
GTTTTATCTTTTCGTGATGTTCCTGCGTCTACTCCACAAGACCGTTTGAACAGCTTCATA
TCTGTTGCTGCTCAGCTTGCAATGGAGAGATTCAACAGACTATTAAATAGACCAAAAGGA
ATATCAAAGGATGAGTTTGATAAGCTCCCCGTTCTGCAAGTTTCTGATCTACCCAAGGCC
GAAGGGCCCTTATGTAGTATATGTTATGACGAATATGAAGATGAAGTTGATTCAACTAAA
GCAAAAAGAAAAAGGGATTCTGAAAATGAGGAGGAATCTGAAGGAACAAAAAAAAGGAAG
GATAATGAAGGTGCGCCCCTACGCACAACCGCCGATAATGACAGTAACCCATCGATTACA
AATGCTACGGTTGTTGAACCGCCTTCTATTCCTCTCACTGAACAACAACGCACTCTCAAT
GATGAAGAAACAAATCCAAGCTACAAACACTCACCAATCAAGTTACCTTGTGGCCACATT
TTTGGGAGGGAATGTATCTACAAATGGTCAAGATTAGAAAATTCTTGTCCCCTTTGTAGA
CAAAAGATCAGCGAATCTGTAGGTGTTCAACGTGCAGCCCAACAAGATACGGATGAAGTA
GCAGCTAACGAAGCTGCTTTTGAACGTATTAGACGAGTTTTATACGACCCAACTGCAGTG
AATAGCACTAACGAAAATAGTTCCGCCCCATCCGAAAACACGTCCAATACAACGGTTCCC
ACTATCGGAAATGCAAGTTCTGGCGAACAGATGTTATCAAGAACAGGCTTTTTTTTAGTG
CCTCAAAACGGCCAACCTTTACACAATCCAGTCCGTTTACCGCCTAATGATAGCGATAGA
AACGGTGTCAACGGGCCGAGCTCAACTACTCAAAATCCACCCTCTAATTCTGGTGGTTCG
AATAACAATCAAAGTCCGCGCTGGGTTCCCATCCCTTTGACTTTGTTCCAATTCCACAGT
CCAAATCCGAATCCTTCCGCTTCTGATTCTTCGGCAAGCCCATCAGCAGCGAACGGTCCA
AACTCAAATAACACTAGTAGTGACGCTACAGACCCTCACCACAACAGACTAAGAGCCGTT
TTGGATCACATATTCAACGTTGCTCAGAGGGGAACTTCTGATACCTCTGCAACAACAGCA
CCCGGAGCACAAACTGTTCACAACCAAGGACGTAATGACTCATCGTCCTCTGATACAACG
CAAGGAAGTTCCTTTTTGGAAAATATTTCACGATTAACAGGCCATTTTACGAATGGCTCA
AGAGACAACAATAACGACAATAACCATAGCAATGATCAACAACGAGGTGGAAGTACTGGT
GAGAACAACAGAAATAACTTGTTTTCCTCCGGTGTTGCCAGTTATAGAAATCAAAATGGT
GATGTTACTACCGTCGAACTACGCAACAACAATTCTGCTGCCTTTCCTCCTACAGACGAA
AATCCCTCTCAAGGCCAAGGTTCAAGCAGTTCGGACACCACCATTCATAACGACGTCCCT
AATGATAACAATGAGCAACGATCATCACAATAA
Promoter Sequence
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>SAN1 YDR143C
GGTGGATTCTATCTTTCTAATTGGTTAAGCGATTTTCAGCTAGTCACAGATAGTCGTTCA
AACATTTGTATACTAGGTATTGCACCGCAGTCAGATCCGACCATTATTTTGGGTGATAAC
TTCTTAGCTAATACTTACGTGGTATATGATCTGGACAATATGGAGATATCAATGGCTCAG
GCTAACTTCAGCGACGACGGTGAATACATTGAGATTATAGAGAGCGCGGTTCCAAGTGCT
CTTAAAGCACCTGGTTACTCAAGCACTTGGTCTACATATGAAAGTATTGTCTCCGGCGGC
AACATGTTTTCCACGGCAGCTAACTCCAGTATATCGTACTTTGCTTCCACGTCTCATTCG
GCAACAAGTTCTTCCAGCTCCAAAGGCCAAAAAACCCAAACAAGTACGACAGCTCTCTCT
ATTTCAAAATCTACCTCAAGTACTTCCTCAACAGGAATGTTATCTCCCACCTCAAGTTCA
TCTACGAGAAAAGAAAACGGAGGACACAATCTGAATCCTCCATTTTTCGCCAGGTTCATT
ACAGCTATTTTTCATCACATTTGATAAATCCCTCCCTCCATATAAGCATTTACTAGACTT
TAAAAGTTGCAATGTATATCTGGAGGTATAACATTGTACATTACTTGAAAGAAAAGCGTC
TTTTAACGTAAAATAAATAATACTGTTCTTTTTTATTGTTACTGGCTTCTTAATCAACAA
TTATATACTTCGACGCAAAAAGCCGGGTAAAACATTCTATCTGCCATTGTCAAAAAATAT
GAAAGAATTTTTTACATATAACTACATTGCATTAGTATCACCAAATCAATAATGAAATAA
TAGCTAAAAACTATATATTGAAGGAAATATAGTTTATCATATATATCCTCTAGTGAAGCT
ACTATAGATAGAAATTATTTAGCATTTCAGGATAGTTCGTTTCTCCCTTTTTTCCCCTTT
GTTTTCTCTCATAGTCTTGTAACCTCAGCTTTTGTTCATT
Chr coordinates
Chr IV from 743874-742042