Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name SCC2
Systematic Name YDR180W
Strain S288c
Description Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2; conserved role in NHEJ
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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Promoter Sequence
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>SCC2 YDR180W
TTTTAGCTTATTCAACTTCAACAGAAGCAGCAAATATGAACACTGCCGAAATTCAAGAAA
CAGCATTTCTACAAAGATATATTTTTACTTTTTTCACCGATGATTTTTTCAAATTATCTA
TGAGGAAGCCATTCCTATTCTCAATATGCAGAACGCTTCAGCATTGGATCTCTAAATTAA
ATGCGTTAAACAGGGTCATGTATAGAACATTTGACAATATTGTTCAAACTAAAATTACCA
GCCCTGTGACAATTGGCAACTTATTCTCATTATTACGACATTCTTTGTTTCCTAATGACA
ATATGATGGGGCCACCAAGAGTATTACCAGTGGGTGATGCTTTTCTAGAGTTCAGAGAAG
AGTGTATTTCCAATTTATGGGATGTTTGTATGACTTATAAACTTGATCATATCCTCGCTA
TCAAAAGGTCTGACATAGCGGATCTTATTATCTGCATATCGAAGAATAGGGATTGCAATA
AACTGCTAATTTATAGAATTATTGACTGTGTTATTGCGCAGTTGCCGTAGACTTCGTGAT
GTATAGAGTATTGTTGACAAATATTTGATGTTACCGAAATAGCACTCTTTGTAGCATTAT
TACCAATTTTTATACTATGAAGTAAGGTCTTAGGAAGCAAGAACATTGTTAACAAATAGC
TTTTATGACCTAATCATTAGCACTATTCATTGCCAAATATGCAAATATCTATTCCTTTTG
CCCGAACAGGTAAAAGTGGTATTGCTTTTATGTTAAACGCGAAACTGCCGCCACTTCGCT
TAAAAAAAACACTGGCTGAAAAAGAACGATGCAGTTTAGTAACTAAAGTTTTTTCTAGCT
CAGGCTTAGAGTTCGATAACAACAAGTCACATTCGAGTGCTCCACTTATAGCAATTTTTC
TTTTGTGTATTGGTTTGCTCCTGTGTGCTCAGGCTTTTCGTTTGTTGTGAGAGTATTGTT
CTTATAACTATTCATTTTTTGAAAGAATTGGCGGCTAGCA
Chr coordinates Chr IV from 821295-825776
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