Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name RSP5
Systematic Name YER125W
Alias HPG1, MDP1, MUT2, NPI1, SMM1, UBY1
Strain S288c
Description NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p, Sem1p, Dip5p and Put4p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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Promoter Sequence
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>RSP5 YER125W
ATATTTCTACCTTTTTATATATTGTAAAACGTTTACGCACTTATTTATGTAAACCAGTAA
GCACCCACCCAGCTATGTCGTCATGACTACAAATTGGTTATGAACCAAGCCTTATTCAGT
AAACCAGCAAATTTAACATCATGCCGGCATTGAATCATACATAGAAATCAACACAATAGC
TTTGAGAACTGAGAATGTAGCTTTGACGCTGCTATTATTATTTGGTATTGTTTACCTTTT
AATGTTTATTTGTTTAGAAAACAGACTGCTGGTTTGTTTACATTTGAGAGCAGAAAAAAA
AAATTGCTGGCGCAGACCAGCCGCACAGTCACGTGACAGTATACGATCATGTGATCTTAC
GTACATAATGACATTATACGAGAAAGGGGAAAAAACAAAAATTTAGTGGAAATTTTTGGT
AAAGACCAAATTGCAGTGATCTTCATGGTGAAAGGTAATATTTTTTGCTGGCGGGGGAGG
GGGCTTCTATCTCGACAATTAAAAGACATACGCTTAACCATTTTTAGGGTACTCGAGTAT
CGCATCTGCTAATTGATAAAAGGACTTTGTTGTGTTTTGAGGCTGTTTTCCATTTTCTTC
GTTAGAGCTACAAGAGTCGACTTTTTCGTTAAACAAAAACGATTATAAGATAATAAGCGC
TGTCAGTTTTTTCCACAGTTTTGGACTTGTTACTATAATTCGTGAAGCACATTTTGCAAG
TGAGTCAAAATTTCAGTTCAGTCCTTCTTTAGAAGAGTGAGTGCGTAGCAAATAAAACAG
CAGGAAATAATTGCTTGTTTTTGTGTGTAAGTACCTTTTAGTTGGAACTACCGAATATAG
TGTTATTCGACTTTCACTTTCATAAGCCACAGCTTTTTCTTAGTGCGTTTTTAGTTCGAT
AAATTTACCAAAAACTATTTTCCCCTTTTCTTATTCCCTTTTCTTTGTTAGCTTGGGTAT
TATATTTAAAGTAACAGAAAGGAAAGAAAAAAGAAAAAAA
Chr coordinates Chr V from 410189-412618
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