Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
ESP1 Systematic Name
YGR098C Alias
separase Strain
S288c Description
Separase/separin, a caspase-like cysteine protease; cleaves Mcd1p/Scc1p, a mitotic cohesin complex subunit, resulting in the dissociation of cohesin from chromatin and sister chromatid separation; cleaves meiotic-cohesin subunit Rec8p along chromosome arms in meiosis I and at centromeric sites during meiosis II; inhibits PP2A-Cdc55p to promote mitotic exit; inhibited by Pds1p (securin); relative distribution to the nucleus increases upon DNA replication stress External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>ESP1 YGR098C
ATGATGGTAAAACAGGAGGAACCGCTGAATGAGATTAGTCCGAATACTCCGATGACTAGC
AAGTCCTACCTTTTAAACGACACGCTTTCGAAAGTACATCATAGTGGCCAAACTAGACCA
CTGACCTCGGTGTTGTCTGGAGACGCCTCATCCAATTCTATTGGCATACTAGCAATGCAT
AATAACATAATACGTGACTTTACAAAAATTGCAAGCAATAACATAGACTTAGCCATTGAG
GATATTACCACTGTTGACCATTCATTAAATTCAATATATAGCCTATTGAAGAGCCATCAC
ATGTGGGGCCATATAAACTCCACTGTTAAACAACATTTGATGATAATTGTTAAACTAATA
AATAATAACGCATTAGGATTGGCCTCCTCTGAAATTATTTTTCTTTTCAATGAAACGAAT
TTATTTCAAGCTCATAGTCTGAAAAACATTCTTCTAGCAGACTTCAGTACGTGGAACGAC
TACTATCTTTCAAATCTGAAAATATTAGCGCTGCAGATTATACTGAAAAGAAAGCTAGTA
GACGAATACTTACCGCATATATTAGAACTATTTTCCCATGATAAAAGATATCTTTTGAAA
GACCCTAACCTCAAAGCTCACGCTCTCACAAAAATCGTGCTGAGCTTTTTTTCTGTCACG
ACGAGTTGCAAAGTTCTATTCGGGCTAAAATTTCTACAATATATCAAACAGTTCAAATTA
CCTTTTAAAAAGTTCATTAGCAACATTACCGTCGAGTGTTTTAGCAAAAACCTTCTTCAT
AAAAATTATTTGGAGATGGGACCTAATAAAATATATTTAAATTCATTTTACTTATCCTAT
TCCATGCTGTACGATGGATTGGATAAAATAATGCTTCTAGACATTTTAAGTTACGAAGAA
ACTACTGAGGTACAAAGAGCGATAAAAAGTAAAAAAGAATTCAATGAATACTGCAACATG
AGTGAAAACCGTCTTCTCTGGTCCTGTATATCTGTCGATGATTTGAACGTAATACTCGAA
AATGCAACGAATTTTCTACAAAATAAAGGGAAACATATATCCGCAACATTAAAATGTTTA
GTCTGTCTTTGGTCTACTATTCGCCTAGAGGGATTACCTAAAAATAAGGATATATTGAGG
CAGTTTGATTGTACTGTTATTTATATCAACTCAAATATTAAATCCATTAATGACGAATCT
GCGGCGGCATTATTATCCGAACTTCTGGGAGTTTTATCAGAAATTTGTATCGATTATAAA
GAGCCTAAACGACTGTCAAATATTATCAGTGTCCTTTTCAATGCTTCTGTTTTATTTAAG
AGTCATTCGTTTTTGTTAAAGACTGCTAATTTGGAAATCTCAAATGTTTTAATCAGTAAT
GATTCAAAAACATCTCATCGTACTATACTGAAATTTGAAAAATTTATATCTAGTGCTCAG
AGTGCCCAGAAAAAAATTGAAATCTTTTCCTGTTTGTTCAATGTATATTGCATGCTACGA
AATGATACGCTATCATTTGTTTTTGACTTTTGCCAAAATGCATTCATTCATTGCTTTACA
CGCCTAAAAATCACAAAATTCATCGAGTTTTCAAACAGTTCAGAAATTATGCTTTCAGTA
CTGTATGGAAATTCATCTATCGAAAACATTCCTTCCGAAAATTGGTCACAACTAAGCAGA
ATGATATTTTGCTCACTGAGGGGTATCTTTGATTTGGATCCTTTAGAGCTAAATAATACG
TTTGATAAATTACACTTGCTCAACAAATATGAGCTATTAATACGAATAGTGTACCTATTG
AACCTGGACATGAGTAAACACCTGACAACGAATCTATCGAAAATAACTAAGCTGTACATA
AACAAATGGCTACAAAAATCAGATGAAAAGGCCGAGAGAATATCGTCATTTGAAATGGAC
TTCGTTAAAATGCTATTGTGCTACTTGAACTTTAATAATTTTGATAAGTTATCCATTGAA
CTTTCACTCTGTATTAAATCAAAAGAAAAGTATTACTCCAGTATTGTGCCTTATGCCGAC
AATTATTTGCTAGAGGCTTATCTGAGCTTATATATGATTGATGATGCCCTCATGATGAAG
AATCAACTACAAAAAACAATGAATTTATCAACGGCGAAAATAGAGCAGGCGTTATTACAT
GCAAGTTCTTTAATAAATGTCCACTTGTGGGACTCTGACTTGACAGCGTTTCAAATATAT
TTTGGAAAAACACTGCCTGCTATGAAGCCTGAATTATTTGATATCAATAACGACCACAAC
CTACCCATGTCACTTTACATCAAAGTCATACTTTTGAACATAAAAATTTTTAATGAAAGC
GCGAAATTAAATATTAAAGCTGGTAATGTTATATCCGCAGTAATTGATTGTAGAAAAGCA
CAAAATTTAGCATTATCGTTGCTCAAAAAGAAGAACAAATTGTCACAAGGATCCAGGCTA
GCATTACTAAAAAGTCTATCGTTTAGTTTTTTCCAACTCATTAAAATACATATACGCATT
GGTTCTGCCAGAGACTGTGAGTTCTACAGTAAAGAACTGTCTAGAATTATTTCTGACTTA
GAGGAACCTATTATCGTCTACAGATGTCTGCATTTTCTTCACAGATACTATATGATTACA
GAGCAAACCTGTCTTCAAAATATAACTTTGGGAAAAGCCAATAAGGCATTTGATTATCTT
GATGCTGAGGCAGACATTACAAGTTTGACAATGTTTCTGTATGATAATAAGGAATTTGTA
AAGTTAGAGCAGTCGTTGGTCCTATATTTCGGTGACCAGCTAGAAAAAACATTCCTACCT
AATTTGTGGAAGCTTCACTTGGGTAAGGATATTGACGACAGCATTTGTCTGTCCGAATAT
ATGCCCAAAAATGTAATCAATAGAGTACACAATATGTGGCAAAAAGTAATGAGCCAATTG
GAGGAAGATCCTTTCTTCAAAGGTATGTTTGAATCTACCCTTGGGATTCCCTCTTCTCTG
CCTGTTATTCCTAGCACGATGCCCAACAACATTTTAAAAACTCCTTCCAAGCATAGTACA
GGATTGAAGCTTTGCGATTCACCAAGATCGTCGAGCATGACGCCTAGAGGTAAGAATATA
AGACAGAAATTTGATAGAATTGCTGCTATTAGTAAATTAAAACAGATGAAAGAACTTTTG
GAGAGTTTGAAACTAGACACATTAGATAATCACGAACTGTCCAAAATTTCCTCCCTTTCT
TCATTAACTCTGACTATCCTTTCAAACATAACTAGTATCCATAATGCTGAGAGTAGTTTG
ATAACTAATTTTTCGCTAACTGACTTGCCAAGGCATATGCCTTTGTTATTCGATAAGGTA
TTGAATAATATTGATAATAAAAATTACCGAGAATTTCGCGTTTCATCACTAATAGCTCCG
AACAATATATCCACAATTACAGAGAGTATTAGAGTATCTGCCGCCCAGAAGGACTTAATG
GAGAGCAACCTTAATATTAATGTTATAACTATTGACTTCTGTCCCATAACTGGAAATTTA
CTTCTATCCAAATTAGAACCGCGACGTAAGAGAAGGACGCATTTAAGGCTACCGCTAATA
CGATCTAATTCAAGAGACCTCGACGAAGTTCATCTCTCATTTCCGGAGGCTACAAAAAAA
CTACTTTCTATTATCAATGAAAGCAACCAAACGACGTCAGTGGAAGTTACCAACAAGATT
AAAACAAGAGAAGAAAGAAAATCTTGGTGGACCACAAGATATGATTTGGATAAAAGAATG
CAACAATTGTTGAATAACATTGAAAATAGTTGGTTCAATGGCGTTCAAGGGTTTTTTAGC
CCTGAAGTAGTCGACAACTCGTTATTTGAAAAATTTAAAGATAAATTTTACGAAATTCTG
CATCAAAATCTTCCTTCCAGAAAACTCTATGGCAATCCGGCAATGTTTATAAAAGTTGAA
GATTGGGTAATCGAATTGTTCTTGAAACTTAATCCGCAAGAAATCGATTTTCTTTCGAAG
ATGGAAGACCTGATATACTTTGTTCTTGATATTCTTCTCTTCCATGGTGAAGAAAATGCT
TACGACGAAATTGATTTCAGCATGCTTCACGTGCAGTTAGAAGAGCAAATAAAGAAATAT
AGGGCAACTATGACAACTAATAGTATATTTCATACATTTTTAGTCGTTAGCAGTTCATGC
CATTTATTCCCTTGGGAGTGTCTTTCATTTTTGAAAGATTTGTCTATCACACGTGTTCCG
TCCTATGTTTGTCTGAATAAACTTTTATCGCGTTTCCATTACCAACTACCCCTTCAAGTA
ACTATTGAGGACAACATTAGTATGATATTAAATCCGAACGGAGATTTGTCCAGGACTGAA
TCTAAATTCAAGGGTATGTTCCAAAAAATAATCGATGCAAAACCTTCCTCTCAATTAGTG
ATGAACGAGAAGCCGGAAGAGGAAACACTTTTGAAAATGCTGCAAAATTCTAACTTATTC
GTTTATATAGGGCATGGCGGAGGTGAACAATATGTAAGGAGTAAGGAGATTAAGAAATGC
ACCAAAATTGCCCCCAGCTTTTTACTGGGCTGCTCTTCAGCAGCGATGAAATATTACGGC
AAGTTAGAACCTACTGGAACAATCTATACTTATTTGCTGGGAGGATGCCCTATGGTACTA
GGTAATCTGTGGGATGTAACTGACAAAGATATTGATAAATTTAGCGAGGAACTTTTTGAA
AAGATGGGATTTCGCTGTAATACTGACGATTTGAATGGTAATAGCCTATCTGTTTCATAT
GCCGTCTCTAAATCTAGAGGTGTATGCCATCTACGTTACTTGAACGGCGCAGCTCCTGTT
ATTTATGGGTTACCGATCAAGTTCGTATCATAA Promoter Sequence
Download FASTA
>ESP1 YGR098C
AATAACATATCTGCCGCTAGCACTGGGTTAAGCAAAAATGATGAAACTAACCATTCCCCT
AAAAACCCAGGTGGATCTGTTTCATTACTCTCAAGTAGAAATTTCCACTGAAGCCGAAGG
TATCCCAAATATTTCGCCATATCAATTCGGTTGGCCAACACATTAAATAACTTGCTCCCA
AAGAAAAGGGCCTTAATGCTATCACGGTCTGCTTTGCTAGTAGTGCTTGCCTTTAAATAA
AAAGTCAAACATCCCGGTTCAAAACTGATGATGTCTTCTAAAATTTCTTGGTATATGCGT
ATCTCTTGCAGTCCATCGCGGCCACTTATTGTCCTTGAGAAGGTGACAATTTGGCATAAA
AATGTAAACGATTTAGAAGCTAGCCGTCTCAATATCACCTTCGATCTTTCTGGTAGTGAT
GGATAAACTGGAATTACGAATTTTATGAGAACCATCGAGGCATCTAGATCCACCGGTTCG
CGAGGATAGGAATCTAGTTGTATTAAAGCTTCATGTATTTGACTGCTGTCAAGCCCTTGT
TTCAGCGTTTCTAAAACCATTTCATGAGGAATTAAATGCGTATAAAGTAGCTCGATTCAC
GTTCTATTAGCGGCAACCTGTCCACAAGTACTTATTGTCTGCATTTCTTGGTGTTTGTTT
TTATTTTCTTTCTTTTCAAACTTCACGGGTCTTTACAGAAAAGAGGTAAACAAACAAAAA
CAAGAACATGGATACAAAGCCCATCCACGTAACATTGCGCATTTGAAGCGAGAAGCTTAC
CACAATTAGTTAAATTCCTTTTGGAGGAATATAGACACTCTATCATCAGAAACATCCGAA
TTATTTTAGTTAGGACACGTTTCACAGGAGCATCTGGCTATAGCATATTTTTCTTTTCCT
TCTAACTGCGAGCATAGTAAAAAGTTGACCTAAACCCAACATTTTTGAGGCTAACCTAGT
AATAATTTAACCTAGGCACGAAGTGCTTATAAATTAAGGA
Chr coordinates
Chr VII from 687458-682566
