Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name LSB1
Systematic Name YGR136W
Strain S288c
Description Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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Promoter Sequence
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>LSB1 YGR136W
TTCTCCCCTGAGGGACGTCTATATCAGGTTGAATACGCGCTAGAATCCATTTCACATGCA
GGTACCGCAATTGGGATTATGGCATCTGATGGGATTGTTCTTGCAGCAGAACGCAAAGTC
ACAAGTACTTTACTAGAACAAGACACCTCTACCGAAAAACTTTATAAGTTAAACGATAAA
ATTGCGGTTGCCGTTGCTGGACTGACTGCAGATGCAGAAATTCTAATAAATACGGCTAGA
ATTCACGCTCAAAATTACCTTAAAACCTATAATGAAGATATACCAGTAGAAATTTTGGTG
AGAAGGCTAAGTGATATAAAACAAGGTTACACGCAACATGGTGGTTTAAGACCATTTGGT
GTGTCCTTTATCTACGCCGGTTATGACGATAGATACGGTTACCAATTGTATACATCTAAT
CCATCGGGAAACTATACAGGGTGGAAGGCTATTAGTGTTGGCGCTAACACATCAGCAGCA
CAAACCCTACTTCAAATGGACTACAAGGATGATATGAAAGTCGATGATGCCATTGAACTG
GCTTTAAAAACGTTATCCAAAACTACCGACAGTAGCGCGCTGACTTATGACAGGTTGGAA
TTTGCTACTATCAGAAAGGGTGCTAATGACGGAGAAGTGTATCAGAAGATTTTCAAGCCT
CAAGAGATAAAGGATATATTGGTAAAGACTGGTATTACCAAGAAGGATGAAGACGAAGAA
GCTGATGAAGATATGAAATAAGGTTGGAAAGTATTGTTTGACTTCATGCTTATATAAATA
TGTACGCATAGAAACATATCTCTAAAATTAAAAGTGAAAGAAAAAAATCGCTAAGATTCC
CCTTTCGGGGGAAGGCTGAAGAAACTTTTTTTTGCGCAAATTTCAAGATCGGAATCGCTC
GAGAGGCAAATATAAAAAAGGGCCTGCTCGTTTGGCCTACTTGTTGTTGGATTCTAACTC
CAATCTAATTTTGGCAGCACTTCAAAAATAAACAAAAGCG
Chr coordinates Chr VII from 762428-763153
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