Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
LSB1 Systematic Name
YGR136W Strain
S288c Description
Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication External sources
Open in SGD
Open in KEGG
Gene Sequence
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>LSB1 YGR136W
ATGTCTGCGTCACTAGTGAATCGATCATTGAAAAATATAAGGAATGAATTAGAATTTTTG
AAGGAATCAAACGTCATATCAGGCGACATTTTCGAATTAATCAATAGCAAGTTACCTGAG
AAATGGGATGGAAACCAAAGATCGCCCCAAAATGCAGATACAGAAGAGTACGTTGAAGCT
TTATATGATTTTGAAGCTCAACAAGATGGAGATTTGTCATTGAAAACAGGTGATAAAATA
CAAGTTTTAGAGAAGATTTCTCCAGATTGGTATAGAGGCAAGTCAAATAATAAGATCGGA
ATATTCCCTGCAAATTATGTGAAACCTGCTTTCACGAGATCAGCCTCACCTAAATCTGCG
GAAGCTGCTTCAAGCTCGACTGTTTCTCGTCCCAGTGTTCCACCTCCATCATACGAACCA
GCCGCATCACAGTATCCTTCACAGCAGGTTTCAGCACCTTATGCACCTCCAGCCGGTTAT
ATGCAAGCTCCGCCTCCACAGCAACAGCAGGCGCCTTTACCATATCCTCCACCTTTCACT
AATTACTATCAACAGCCTCAGCAACAGTACGCACCACCTTCACAGCAAGCACCGGTGGAA
GCACAACCGCAACAGAGCAGTGGGGCTAGTAGTGCCTTCAAGAGTTTTGGTAGCAAATTG
GGAAATGCTGCTATATTTGGCGCTGGTTCTGCTATTGGTAGTGATATTGTCAACAGCATT
TTTTAG Promoter Sequence
Download FASTA
>LSB1 YGR136W
TTCTCCCCTGAGGGACGTCTATATCAGGTTGAATACGCGCTAGAATCCATTTCACATGCA
GGTACCGCAATTGGGATTATGGCATCTGATGGGATTGTTCTTGCAGCAGAACGCAAAGTC
ACAAGTACTTTACTAGAACAAGACACCTCTACCGAAAAACTTTATAAGTTAAACGATAAA
ATTGCGGTTGCCGTTGCTGGACTGACTGCAGATGCAGAAATTCTAATAAATACGGCTAGA
ATTCACGCTCAAAATTACCTTAAAACCTATAATGAAGATATACCAGTAGAAATTTTGGTG
AGAAGGCTAAGTGATATAAAACAAGGTTACACGCAACATGGTGGTTTAAGACCATTTGGT
GTGTCCTTTATCTACGCCGGTTATGACGATAGATACGGTTACCAATTGTATACATCTAAT
CCATCGGGAAACTATACAGGGTGGAAGGCTATTAGTGTTGGCGCTAACACATCAGCAGCA
CAAACCCTACTTCAAATGGACTACAAGGATGATATGAAAGTCGATGATGCCATTGAACTG
GCTTTAAAAACGTTATCCAAAACTACCGACAGTAGCGCGCTGACTTATGACAGGTTGGAA
TTTGCTACTATCAGAAAGGGTGCTAATGACGGAGAAGTGTATCAGAAGATTTTCAAGCCT
CAAGAGATAAAGGATATATTGGTAAAGACTGGTATTACCAAGAAGGATGAAGACGAAGAA
GCTGATGAAGATATGAAATAAGGTTGGAAAGTATTGTTTGACTTCATGCTTATATAAATA
TGTACGCATAGAAACATATCTCTAAAATTAAAAGTGAAAGAAAAAAATCGCTAAGATTCC
CCTTTCGGGGGAAGGCTGAAGAAACTTTTTTTTGCGCAAATTTCAAGATCGGAATCGCTC
GAGAGGCAAATATAAAAAAGGGCCTGCTCGTTTGGCCTACTTGTTGTTGGATTCTAACTC
CAATCTAATTTTGGCAGCACTTCAAAAATAAACAAAAGCG
Chr coordinates
Chr VII from 762428-763153
