Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name UBR1
Systematic Name YGR184C
Alias PTR1
Strain S288c
Description E3 Ub-ligase (N-recognin); recognizes and ubiquitinates N-end rule pathway substrates in complex with Rad6p; Roq1p-bound form accelerates degradation of misfolded and native ER membrane and cytosolic proteins as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; role in ER-associated protein degradation; modifies Cup9p to regulate peptide transport; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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Promoter Sequence
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>UBR1 YGR184C
CCCCGGTAACGTCGAAGAGAATGGTTTACTGTCATTTGTCCAATATGTCATTGCACCAAT
CCAAGAATTGAAGTTTGGTACAAATCACTTCGAATTCTTCATTGATAGACCAGAAAAGTT
CGGTGGTCCAATTACCTACAAATCCTTCGAAGAAATGAAATTGGCTTTTAAAGAAGAAAA
ATTGTCCCCACCTGATCTAAAAATTGGTGTTGCTGACGCTATCAACGAGCTATTGGAGCC
AATCAGACAAGAATTTGCCAACAACAAGGAATTTCAAGAGGCCTCCGAAAAGGGTTATCC
AGTTGCCACACCACAAAAGTCGAAAAAGGCTAAGAAACCAAAGAATAAGGGTACTAAGTA
CCCAGGCGCTACTAAGACCAACGAGATTGCCACGAAACTAGAGGAAACCAAATTGTAAGC
ATAGCTTAATCCGTTTTCACGATTCATAATATAATAAATAAGAAAAGATATATCATATAA
ACGTTATAAAATTAATAACCGGGTAAGTGTAGAAAAGTGATGCGACGGTTTATTTTCTCT
TCCTCTTGCGATTGAATTTAACTTGCAGATAGTGACCATAAGGCAACTACCCAGTGGCAA
ACAGTTTTGATAACGCCCAGTACATCAACGAGCGAGTATAAAGACTTTGGTACATTTTAA
AAAGGAAACATATATTGTTTTCATTGCTAGACCCTTTTAGTCTCACCTCAATAAAACTGC
TTTATTCCTCATTGGGCTTTTTATTCTTTAATTTTGCATACTTATAGCGTGAAACTGGGC
ATTTAACAAAAGCAAACTATTTTAATAGTAGCATCCTGCTTTCTTTGCCCCTCCTTCTTA
TTGCGATACATTATTAAGTTTTTTTACCACCTTTCTTCCTTTTTCTTCGCATCTTCGGAC
AAAGGCAGTTGAAGTTTACTGTATCCTATTAGTTGACTATTTTCTCTCACTGAAGTCCCT
AATCTTTACAGGTCACACAAATTACATAGAACATTCCAAT
Chr coordinates Chr VII from 865753-859901
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