Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name BUB1
Systematic Name YGR188C
Strain S288c
Description Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication
External sources Open in SGD external link
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Gene Sequence
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Promoter Sequence
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>BUB1 YGR188C
TATGTTTCATTATTACATTATCAATCCTCGCATTTCAGCTTCCTCTAACTTCAATGACCG
CTTCTCATAACTTATGCCATCATCTAACACCGTATATGATAATATATTAGTAAAACGAAT
ACTACTAAATAAAAGATAATTTAGAGTTTCATTCCAACAATAGATGATAGTTGTAGTCCT
TATTCTAACAGTTTATAATTCTCGAAGAAAACTTCTATTACATTTATGCCACAGTTACCC
TTTCTAATAGGAAACTAAGTTCCATAAATTGTCATCAAGTTCTAACGCTGCCAAGATAGA
AAACCATCAAACGTTAAAATATAAAGTGCGGTTGGATAAAAACTAGAGACATCGACGCTG
TACGAAGAAAATATCGAAAGCTATCTCAAGGAACATAAAAATCCAATTCTGTAACAATTA
TATGCTGAATAGGTAAATTACAAAATAGAATTGTTAGATTTCGTTCTTAGCGAAGACAAT
AATGATATATAACATATATCAAAACATTCTCCTTTTGAGGTATTGAAAACATGCAAGTAG
AAAGGCAATTGAACGTTTTATGTAATGGTTTCTTATCTTGATTTTATACGTCACCTCTCA
TTAATCCTTTTATCCCCCCAATTCTCATGGTTCAGTTTCCATTGAATCTGATGACAGTTG
AGTTTTATTCTACCGACTCCATAACTTGTGCCAACTTTTAAAATAGTTCAAGGTAATGTC
TTAATGAATTCTCTACTAATTAATGCTCAATAGCTGGTTTTTATTTTAGGAGTGTGTTTA
ACGTTTGACTTCACGTCCATGGGGTCATCTTGTAACGGACACGGTTTTTTTGGTCTTTCA
TTGTTTTCGCTTTCGATACGCGCTAGGAAGTAAATAAAGAAAAAAAAGCGTTGTTCATAT
ACATACACAATATACGTGATTTTAGAATAGAGTATAAAGTTTTCATCATGGAAAGATTAT
TGACGGTTCCTATTGTTTGAATGTTAACGCTGACCAGGAA
Chr coordinates Chr VII from 875109-872044
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