Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
PRP8 Systematic Name
YHR165C Alias
DBF3, DNA39, RNA8, SLT21, USA2 Strain
S288c Description
Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA View Seq
Sequence hidden Promoter Sequence
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>PRP8 YHR165C
CCTACTCCAATATTCTATACGTCATGCAGAAGAATTCAAAATTAGCCTATTTGGCGCAAT
TCGTCTCCCAAATAGATAGATTTAGACCGGAAACATGTTGTATCATAGCGAACTATTACA
GTGCCCGACAGGAACATGAAAAATCTATCATGTATTTCCGTCGAGCACTAACTTTGGATA
AAAAAACAACAAACGCATGGACTTTGATGGGTCACGAATTTGTTGAACTAAGCAATTCAC
ATGCCGCAATAGAATGCTATCGTCGGGCCGTAGATATATGCCCTCGAGACTTCAAAGCAT
GGTTTGGTTTGGGCCAGGCTTATGCTCTCCTGGACATGCATTTATATTCTCTTTACTACT
TCCAGAAAGCTTGCACTTTGAAACCTTGGGATCGTCGGATTTGGCAAGTATTGGGAGAAT
GTTATAGTAAGACGGGAAATAAGGTAGAAGCTATAAAATGCTACAAAAGATCCATAAAAG
CTTCACAAACGGTCGATCAAAATACTTCAATATATTACCGGTTAGCGCAACTATATGAAG
AACTTGAAGACTTGCAAGAATGTAAGAAGTTCATGATGAAATGTGTAGATGTGGAAGAAC
TTCTGGAAGGTATAGTAACAGATGAAACCGTGAAGGCTAGGCTTTGGCTGGCAATATTTG
AGATTAAGGCAGGAAACTACCAATTGGCTTATGATTATGCCATGGGGGTATCTAGTGGAA
CGTCTCAAGAGATTGAAGAGGCTCGTATGCTGGCTCGGGAGTGCAGAAGGCATATGTAGT
GAAGTGAACATACACATAGCTATTCGTACTAAATGATATGAAATTTTTATAAATGCCAGG
CTATATAGCTATTTAAAGTGACCATGGCAGAAGGATGAACCGAGGTAATACGGCTAGTAC
AAAAGCAACAAAGTTAGGAATACAATTTGAGAAACGAAGACCATAGAAAATACTTGTGCG
ATTGAACTTCCTTCCAAAAAAAAAATAGCGTCAAAGAAAG
Chr coordinates
Chr VIII from 436948-429707
