Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name STE24
Systematic Name YJR117W
Alias AFC1, PIO2
Strain S288c
Description Highly conserved zinc metalloprotease; component of the ER quality control mechanism that removes faulty proteins clogging translocation channels; inhibits SRP-independent translocation into the ER; has two roles in a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves isoprenylated and non-prenylated oligopeptides; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and complements the null mutant
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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Promoter Sequence
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>STE24 YJR117W
GCACTACACCACGATCCGTGACCCACTGCTGAAAATTGATTTCAATGTCCACACCGTCTC
GATGATCCAGGCTGTCGTCTCGAACACCGTCCTGTTGCCCACCCTCACGACGCCAATGCA
TTATAATGTTGTCACCTACACAGATTCGTACAGTTCAATGGTATCTTCCCTCAGCGCAGG
GTACTTTATCTGGGACTTGACTATGTGCGTGCGTTACTTCAAGCTTTATGGTCTCGAGTT
CACGGGCCACGCCATTGGCTCCGTATATGTGATGCTGTTGTCCTTAAGACCGTTCTGCCA
ACCCTGGATCGGCAGGTTCCTTATCTACGAGGCCTCCACTCCCTTTGTGAACATCAATTG
GTTCATCATGCAATGTAACGCCAAGAGCAAGAACTCTATCCCTCTGTGGTTTAATGTCGT
CAATGGCCTTTTGCTCATGACTGTGTTTTTCGTCGTCAGGATTTGCTGGGGCTCCATCGC
ATCCGCTCTCTTATTCAGGCAGATGTGGAAGGTAAGAGACGAGTTACCCAAGTTTTCTGC
TGTCACGATGATGTCGCTGAACATTTTCATGAACCTTTTGAACGTGCTTTGGTTCAAGAA
GATGATTAGAATCGCCAAGAAACTTGCAAAACCAGCCCCAACGTCGAAGCTAGACTAAAC
CTACCTTTTTTTCTATCTTCAACAACGAAACGCCTTACACACACACACACATACATCTAC
ATACATACATACAAATATACATATATGTAAACTTGTATATTCATTCCTATTAACCAAAAA
GAGGCAATTAAACTTTTCCCTCTTTTTCTACGTCATTTACTCAAAAACTCTAATTCCTTC
GTCTCTGTTCTGCCATTTTCTCCAGAAAAAAATCGACGGGAAATAAAAAAAAAAAGACAA
CGAACAAGAGAAAAAGTTCGCGAATTATAAACCACTTCTATAATTAACAGGAAAAGGAAG
GAAAAAAAAGGAGGAAATAGAAAACTGCAGGCCTTTATTC
Chr coordinates Chr X from 642007-643368
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