Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
CSE4 Systematic Name
YKL049C Alias
CSL2 Strain
S288c Description
Centromeric histone H3-like protein; associates with promoters, accessible chromatin, and RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for kinetochore function; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting bi-orientation; increases association of Sgo1p with centromeric chromatin; proteolysis regulated by multiple E3 ligases, resulting in faithful chromosome segregation; CSE4 complements mutations in the human homolog CENPA External sources
Open in SGD
Open in KEGG
Gene Sequence
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>CSE4 YKL049C
ATGTCAAGTAAACAACAATGGGTTAGTTCTGCTATTCAAAGTGATTCGAGTGGAAGATCA
CTCAGTAACGTCAACAGGCTTGCAGGAGACCAACAATCTATTAACGATCGTGCGTTATCG
TTATTGCAGAGAACAAGAGCGACAAAGAACCTGTTTCCAAGAAGAGAGGAAAGAAGACGT
TATGAAAGCTCAAAAAGTGACCTAGATATCGAAACAGACTACGAAGACCAAGCAGGTAAT
CTAGAAATCGAGACAGAAAATGAAGAAGAAGCTGAAATGGAAACTGAAGTACCTGCACCA
GTGCGAACTCATTCATATGCCTTAGACAGATATGTTAGACAGAAAAGGAGGGAAAAACAA
AGAAAGCAGAGCTTAAAGCGCGTCGAAAAGAAATATACTCCTAGTGAATTAGCTCTGTAC
GAAATTCGAAAATACCAACGTTCCACGGATTTATTAATCTCCAAAATTCCATTTGCAAGG
CTAGTGAAAGAAGTTACAGACGAGTTTACAACTAAAGATCAGGATTTACGTTGGCAGTCA
ATGGCGATTATGGCGTTACAGGAAGCAAGCGAAGCGTATCTGGTAGGATTATTGGAACAT
ACAAACCTCTTGGCGCTGCATGCAAAAAGAATTACTATAATGAAGAAAGACATGCAACTA
GCAAGAAGAATCAGGGGACAGTTTATTTAG Promoter Sequence
Download FASTA
>CSE4 YKL049C
TATTGGTATCTGCAACTAGTAAAGTAACACCTTCGATACATATCGACGAGGAACCGGATA
AAGAATGTTTTTCGACTACGGTCCTTAGATCTTCGCCAGACTCGAGCGATTATTGTTCAT
CGTTAGGGGAGGAAGCCATTCAGGTTACGGATTTCTTAGATACTTTTTGTAGGTCAAATG
AAAGCTTACCTAATTTGACTGTGAATAATGATAAGCAGAATTCGGACATGAAAACTGACA
GAAGCGAGTCATCCTCTCATTCGTCATTGAAAATCCCAACACCTATCAAAGCCATGATAA
GACTAAAGAGTTCCCCTAAAGAGAACGGGAACAGAACCCATATTAATTGCTCACAGGACA
AACCGAGTTCCCCACTAATGGATAGGACTGTTGGAAAGCGCACGGTTAACAATTCAGGGG
CTAGAAAGCTTGCTCATTCAAGTAATATTCTCAACTTTAAAGCATACATAAATTCGGAAG
ATAGTGACATTCGAGAAACAGTAGAAGATGTAAAAACGTATCTGAACTTTGCAGATAATG
GTCAAATATAGATGAAACTACAGGATGATATCTGTCGGATTGGGTTAGCTGATAATCGTA
TAGCCGATGTGAAATATGATTATTAATTGATTTACTTGGTTATGGTAAATACATAAATAT
ATATATAGAAACGGCAAATTACCCACATTTGCATTTGTATTAATAACACTAAAGATAATA
TTCATAATATACCATCATTGATAATTGAAATCGACATCAACATTTATCAATTGAGAGTTT
AGTGGTCTTCTATTGCGAGAATATCGAACGATATGATTTATCTTGATCCCACTGTGTCGC
GAAATCGCGGAAGTAAATTGAAAACAAAAGAAAAACAAAACTTCATCGATAAATATTGAG
AAAACATCTCTTAAAAACAGTAGTAGATAATCTTGAGAATTTACTTTATAAAAAACAGAA
GAAGGACTGAATATAGAAAGAATACTAATATAACATAATC
Chr coordinates
Chr XI from 346764-346075
