Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
TOP2 Systematic Name
YNL088W Alias
TOR3, TRF3 Strain
S288c Description
Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA View Seq
Sequence hidden Promoter Sequence
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>TOP2 YNL088W
ATTGCAGAGTTGACGGAATAAAAGTGTCCTTAACGCTCTGGGATACAGCGGGACAAGAGG
AATATGAACGTTTACGTCCATTCTCATATTCAAAAGCAGATATAATATTAATTGGGTTTG
CTGTAGACAATTTTGAATCACTAATTAACGCAAGGACGAAATGGGCGGATGAGGCATTAC
GATATTGTCCTGACGCACCAATCGTTCTTGTAGGCTTGAAAAAAGATTTGAGGCAAGAAG
CCCATTTTAAAGAGAATGCTACCGATGAAATGGTTCCCATTGAAGATGCAAAACAAGTTG
CAAGGGCCATTGGGGCCAAGAAATACATGGAATGTAGTGCACTGACTGGTGAGGGTGTGG
ATGATGTCTTTGAAGTAGCTACAAGAACCAGTTTGCTTATGAAGAAGGAACCAGGGGCTA
ACTGTTGCATAATTTTATAAAAAAAACTTACACTGAAATGATACATTATCTTTTTAGCAA
GGGAGGGAAAAACAATACCGTATTATAATTTTAATCAAATTTCATAGATATAATGGAATA
AGTTAAAAAGGCTTATCGATAGTGCATGTATAAAACACAAACCCATTCGATATGTTTGTT
CGTTAATGTCCTACAGATTCTTATTCGAGAGCCTTTACCAGAAGCAAAATTTCCGACGGA
TATAAGAAAATGGCACATCAAACCATAGCTCAAGGTACTGCGCCGATGAGCTAAACGGAA
CTGCCTAGTTTGATTATTTTTCGTTTATATACTTATTTACTTATTTACGCTATTTGTATT
CGAATTCCTTACGAGGCGATGAGTGAAAGACGCGCCAGTAGGACGCGTCTTTTTTTTTTC
AGTATAATGTAAACATATTATTGAATTGCCGAAGGAGACAAAAAGAAAAGAAAAGAGGAG
ATCATCTTTCATATAATCCAACCACGTCGTAGAGCAAACCACGACAATTTTAACTTTCTG
TTTCAGTTAAAGGAGTTTATAACGACCAGCACGGCTAACC
Chr coordinates
Chr XIV from 457704-461990
