Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
MSB4
Systematic Name
YOL112W
Strain
S288c
Description
GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>MSB4 YOL112W
ATGATAATGTCATCAACTATGTCGACAGAAGCCGCCTTGGTACCGAACGAAAGTGTTTTT
GACACAGTTTCGTCATTCAACGAAGACGATGCCAATTATAGCGTTCTTGATTTATACGAT
GACGACGATGAAGGGGATGATAGTTCTACAGTAGAACGAAAAGAAATATTGACAACACGT
GAGCTTGAAAAAGCAAAGGCGTTTACCAGCTTAATCATGGCAGATCCTGAGAATTTTGAT
AGATATGGATTTAGCAAGAAAGGATATTTCATTAGTCAGGAAGAATACGACAAATGGTGG
ACAGAATATAATAGATACACCGAAAGAAGAAAAAAAAAGTGGGAGAACTTTCTTCTTAAG
AATAAGATTGAGCTCCACAATGATAATCCTCTAGTATATCCTGCAAGGACAGATGAATTG
TCAAAATTTGTTAGAAAAGGTATACCAGCAGAATGGAGAGGGAATGCCTGGTGGTATTTT
GCTGGTGGACAACGACAATTAGACGCAAATGTTGGCGTTTATGATAGACTGAAAAGTGAC
TGTCGCGAGGGTGCCGTATCTGGTAAAGATATGGAAGCTATAGAACGGGATCTTTATCGA
ACGTTTCCCGATAATATACATTTCCATAAGGAGTCCTTCCAAAATGGAGAGCCGGCGATC
ATCCGATCATTGCGTCGAGTATTAATGGCCTTTTCTGTTTATGACAAGACTATTGGATAC
TGCCAATCGATGAATTTTCTCGTTGGATTGCTATTATTGTTCATGGAAGAAGAGAAAGCA
TTTTGGATGCTGGTTATTATTACCGGTAAGTATTTACCTGGCGTGTATGAATCAGACTTA
GAGGGTGCGAACGTGGATCAAGGGGTGTTGGTGTTATGTATCAAGGAATATTTACCCGAG
ATATGGTCACACATTGAGTCATCGTATATGAATGGCAATGGCAGCACTGACCAGATATCA
GGGCCAGCATCGGGGGAAGAATATCTCTGCAGGCTGCCTACGCTGACGCTGTGTACGGCA
AGTTGGTTTATGAGCTGTTTTGTGGGCGTGGTGCCCATCGAAACGACCCTGAGAATATGG
GACTGTTTATTCTATGAAGAGTCTCATTTTTTATTTAAAGTGGCTTTGGGGATACTGAAA
TTGAGCGAAAGCGAGTTTTTGGAGAGTAAAAGCCAGAAACTGTTTAGACAGTACTCTTCG
TACACCTTCGGTGGTAGTAATGACTCTGATTCAACTTTCAAAAGATTAAAGAACAAGATT
AAGACGCAGGAAGAGGCAGATATGGAGATTTTGCAAGTGATTCAAAATTTCCCAAAAAGA
TTGCTCAATCCGAATGATATCTTTGAGAAAGTCCTGATGAAGAAGAAGGTTGCGTTGAAT
GGTATTACCCAGGAAAAGATTGATCGCGGTAGAGAGTATGTGGCGATGGCGAGAAATAGA
CAAAGGGCGAGTAGCCGCCCAAAGGAAAGAAGAAAATAG
Promoter Sequence
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>MSB4 YOL112W
ATATATTGGATGCTGTAGCAAGGAGCAATACCGGTGAGCACTCATCGCCGTTAAACGAAA
ACCAAATGGCATATATAGTAAAAGAGACGTGCCAAGGTTTGAAGTTTTTGCATAACAAGA
AAATTATCCATCGAGATATCAAATCTGATAATATCCTTCTGAATTCCCAAGGGTTAGTGA
AAATTACAGACTTCGGTTTTTGTGTGGAATTAACAGAAAAAAGAAGCAAGCGTGCCACAA
TGGTAGGTACTCCATATTGGATGGCACCTGAAATAGTGAATCAAAAGGGATATGATGAAA
AAGTCGACGTTTGGTCTCTAGGGATAATGCTTATTGAGATGATAGAAGGTGAACCGCCTT
ACCTAAATGAGGATCCTTTGAAGGCGCTGTATCTGATAGCTAACAACGGTTCACCAAAAT
TGCGTCATCCAGAGTCAGTGTCCAAGCAAACCAAACAATTCTTAGATGCCTGTTTGCAAG
TGAATGTCGAATCAAGAGCATCCGTGAGAAAACTACTAACGTTTGAATTTTTGTCAATGG
CATGCAGCCCTGAGCAGCTCAAAGTATCCTTAAAGTGGCATTGAAATTTAGCTTTTTTTT
ATTTAGGAGAAACAATATATATATATATGTATATACGTATGTATGATTCATATTTTAATC
GCATTTTTATTTCATCTAAAACAATTACTCTTTTTGATTATTTATAGAAAAAAAACAACA
ATGATACGTTTGCTTCGCGTTATGTCAATAGAAAATGTAAAAGGAAAAAGAATGTGTTGC
TATTCGTTAGGCGGATTTACGGATGGAAGACATATCTATGAACTGAGCTTACAAACGCTT
TTAGCGGGGACAGTTAATCATTTTACGGATGATTTTATAAGAATAAACTATTTTTGAAAA
GTTAGGATAGTATTTTGTACATTTGGCACCGAAGTAATTCAAAATCGAGGAAGACTCGCA
CACTTTTACAATCACAGAAGGCAAAACCCGGCATGACAGG
Chr coordinates
Chr XV from 106710-108188