S.cerevisiae - Yeastract

Regulation Reference(s)

The Yeastract team, is actively curating each regulation evidence code, association type and environmental condition.

Transcription Factor	Target ORF/Genes	References	Evidence Code	Evidence Experiment	Association Type	Strain	Environmental Condition
Ixr1p	YDR044W	PubMed Castro-Prego R et al., FEMS Yeast Res, 2010 May;10(3):309-21	Direct	EMSA	N/A	BY4741	Ixr1p binds to sequences extending from -534 to -509, -526 to -516, and from -497 to -450 (P497-450) of the HEM13 promoter, at 0. and room temperature
			Direct	ChIP	N/A	Z1580	Cells grown under aerobic or hypoxic conditions
			Indirect	Northern blot - wt vs TF mutant	Negative	BY4741 and W303	wt vs DELTAixr1: under aerobic conditions
			Indirect	Northern blot - wt vs TF mutant	Positive	BY4741 and W303	wt vs DELTAixr1: under hypoxic conditions
			Indirect	alpha-galactosidase - wt vs TF mutant	Negative	BY4741	wt vs DELTAixr1 cells expressing the HEM13 promoter region P421-179 fused to the reporter gene MEL1 under hypoxic conditions
			Indirect	alpha-galactosidase - wt vs TF mutant	Positive	BY4741	wt vs DELTAixr1 cells expressing the HEM13 promoter region P577-419 fused to the reporter gene MEL1 under hypoxic conditions
		PubMed Liu J et al., Antioxid Redox Signal, 2013 Dec 1;19(16):1916-27	Indirect	RT-PCR - wt vs TF mutant	Positive	S288c	exponential phase
		PubMed Vizoso-VÃ¡zquez A et al., Biochim Biophys Acta Gene Regul Mech, 2017 Feb;1860(2):256-269	Indirect	RT-PCR - wt vs TF mutant	Positive	W303	Hypoxic conditions
		PubMed Vizoso-VÃ¡zquez Ã et al., Sci Rep, 2018 Feb 15;8(1):3090	Indirect	Microarray analysis - wt vs TF mutant	N/A	W303	SD medium
			Indirect	Microarray analysis - wt vs TF mutant	N/A	W303	SD medium + 600 micromolar cisplatin