S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Gpd1p
Description	NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import
GO Terms: Biological Process	level 4: carbohydrate metabolic process level 4: NADH oxidation level 4: intracellular accumulation of glycerol level 6: glycerol-3-phosphate catabolic process level 6: glycerol-3-phosphate metabolic process level 6: protein import into peroxisome matrix
GO Terms: Molecular Function	level 3: oxidoreductase activity level 5: protein homodimerization activity level 5: NAD binding level 5: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor level 7: glycerol-3-phosphate dehydrogenase [NAD+] activity
GO Terms: Cellular Component	level 3: cytosol level 3: cytoplasm level 4: mitochondrion level 4: glycerol-3-phosphate dehydrogenase complex level 5: peroxisome level 5: nucleus
External source	Open in SGD