S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sem1p
Description	19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress
GO Terms: Biological Process	level 3: protein folding level 3: filamentous growth level 4: SAGA complex localization to transcription regulatory region level 5: regulation of cell cycle level 6: mRNA export from nucleus level 7: histone deubiquitination level 7: maintenance of DNA trinucleotide repeats level 7: proteasome-mediated ubiquitin-dependent protein catabolic process level 7: proteasome assembly level 8: ubiquitin-dependent protein catabolic process level 8: double-strand break repair via homologous recombination
GO Terms: Molecular Function	level 1: molecular_function
GO Terms: Cellular Component	level 3: cytosol level 3: proteasome regulatory particle, lid subcomplex level 4: transcription export complex 2 level 4: proteasome storage granule level 4: proteasome complex
External source	Open in SGD