S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ubp6p
Description	Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant
GO Terms: Biological Process	level 5: proteolysis level 7: protein deubiquitination level 7: proteasome-mediated ubiquitin-dependent protein catabolic process level 7: regulation of proteasomal protein catabolic process level 8: ubiquitin-dependent protein catabolic process level 8: mitochondria-associated ubiquitin-dependent protein catabolic process level 8: negative regulation of proteasomal protein catabolic process
GO Terms: Molecular Function	level 3: hydrolase activity level 4: peptidase activity level 4: proteasome binding level 5: cysteine-type peptidase activity level 6: cysteine-type deubiquitinase activity
GO Terms: Cellular Component	level 3: proteasome regulatory particle level 4: proteasome complex
External source	Open in SGD