S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Alg2p
Description	Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in N-linked glycosylation pathway; mutants exhibit temperature-sensitive growth and abnormal accumulation of lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; mutations of human ALG2 cause congenital myasthenic syndrome; human ALG2 complements temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement
GO Terms: Biological Process	level 4: mannosylation level 5: protein glycosylation level 5: oligosaccharide-lipid intermediate biosynthetic process
GO Terms: Molecular Function	level 3: transferase activity level 4: glycosyltransferase activity level 6: alpha-1,3-mannosyltransferase activity level 6: GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity level 7: glycolipid 1,6-alpha-mannosyltransferase activity level 7: GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
GO Terms: Cellular Component	level 3: membrane level 4: endoplasmic reticulum level 4: integral component of membrane level 5: endoplasmic reticulum membrane
External source	Open in SGD