S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Aft1p
Description	Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
GO Terms: Biological Process	level 3: chromosome segregation level 4: meiotic chromosome segregation level 5: establishment of mitotic sister chromatid cohesion level 7: positive regulation of iron ion transport level 8: cardiolipin metabolic process level 8: positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation level 9: positive regulation of transcription by RNA polymerase II level 9: negative regulation of transcription by RNA polymerase II
GO Terms: Molecular Function	level 3: kinetochore binding level 4: DNA-binding transcription factor activity, RNA polymerase II-specific level 5: metal ion binding level 7: zinc ion binding level 7: cis-regulatory region sequence-specific DNA binding
GO Terms: Cellular Component	level 3: cytoplasm level 5: nucleus
External source	Open in SGD