S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Pmr1p
Description	High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant
GO Terms: Biological Process	level 4: ion transmembrane transport level 5: ion transport level 5: macroautophagy level 7: calcium ion transmembrane transport level 7: manganese ion transmembrane transport level 8: calcium ion transport level 8: cellular calcium ion homeostasis level 9: manganese ion transport level 9: cellular manganese ion homeostasis
GO Terms: Molecular Function	level 3: ATP hydrolysis activity level 4: nucleotide binding level 5: P-type manganese transporter activity level 5: P-type ion transporter activity level 5: P-type calcium transporter activity level 6: calcium ion binding level 6: ATP binding
GO Terms: Cellular Component	level 3: membrane level 4: plasma membrane level 4: integral component of membrane level 4: endoplasmic reticulum level 4: Golgi apparatus level 5: Golgi membrane
External source	Open in SGD