S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Dpb11p
Description	DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
GO Terms: Biological Process	level 3: cell cycle level 4: mating type switching level 5: mitotic DNA replication checkpoint signaling level 6: DNA replication initiation level 6: mitotic G2 DNA damage checkpoint signaling level 6: DNA replication level 7: DNA replication checkpoint signaling level 7: recombinational repair level 7: positive regulation of DNA replication origin binding level 9: double-strand break repair via break-induced replication level 9: activation of protein kinase activity level 9: positive regulation of protein phosphorylation
GO Terms: Molecular Function	level 5: DNA polymerase binding level 6: protein kinase activator activity
GO Terms: Cellular Component	level 3: replication fork level 4: DNA replication preinitiation complex level 5: nucleus
External source	Open in SGD