S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hfd1p
Description	Dehydrogenase involved in ubiquinone and sphingolipid metabolism; converts 4-hydroxybenzaldehyde into 4-hydroxybenzoate for ubiquinone anabolism, hexadecenal to hexadecenoic acid in sphingosine 1-phosphate catabolism; human homolog ALDH3A2, mutated in Sjogren-Larsson syndrome, can rescue yeast hfd1 mutant; human ALDH3A1, but not ALDH3A2, rescues pABA- respiratory growth phenotype of hfd1 null; data suggest that dual functions of Hfd1p have diverged in human ALDH3A1, ALDH3A2
GO Terms: Biological Process	level 4: cellular aldehyde metabolic process level 5: sphingolipid metabolic process level 5: aldehyde catabolic process level 7: ubiquinone biosynthetic process from tyrosine level 7: ubiquinone biosynthetic process
GO Terms: Molecular Function	level 3: oxidoreductase activity level 5: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor level 5: carboxylate reductase activity level 6: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity level 7: aldehyde dehydrogenase (NAD+) activity level 8: 4-hydroxybenzaldehyde dehydrogenase activity
GO Terms: Cellular Component	level 3: membrane level 3: cytoplasm level 4: endosome level 4: endoplasmic reticulum level 4: integral component of membrane level 4: mitochondrion level 5: lipid droplet level 5: endosome membrane level 6: mitochondrial outer membrane level 7: integral component of mitochondrial outer membrane
External source	Open in SGD