S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Rkr1p
Description	RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration
GO Terms: Biological Process	level 5: chromatin organization level 5: protein catabolic process level 6: proteasomal protein catabolic process level 7: rescue of stalled ribosome level 8: ubiquitin-dependent protein catabolic process level 8: ribosome-associated ubiquitin-dependent protein catabolic process level 8: protein ubiquitination level 8: subtelomeric heterochromatin formation
GO Terms: Molecular Function	level 3: transferase activity level 5: metal ion binding level 5: ubiquitin-protein transferase activity level 5: ribosomal large subunit binding level 6: ubiquitin protein ligase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: cytosol level 3: RQC complex level 4: chromosome, telomeric region level 5: nucleus
External source	Open in SGD